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Aspartate Carbamoyltransferase (ATCase)

Target: ATCase
Molecular classification: Enzyme

Overview

Aspartate carbamoyltransferase (ATCase; EC 2.1.3.2) is a key enzyme in the de novo biosynthesis of pyrimidine nucleotides. It catalyzes the condensation of L-aspartate and carbamoyl phosphate to form N-carbamoyl-L-aspartate and inorganic phosphate, representing the first committed and rate-limiting step in pyrimidine biosynthesis. ATCase regulates cellular nucleotide pools and is allosterically regulated by CTP (inhibitor) and ATP (activator).

Mechanism of action

Inhibition of pyrimidine biosynthesis

Biological functions

Pyrimidine biosynthesisRegulation of nucleotide poolsCell proliferation

Disease associations

CancerOther - Genetic instability related diseases

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