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Target intelligence / Profile preview
Aspartate Carbamoyltransferase Catalytic Chain (ATCase catalytic chain)
- Target
- ATCase catalytic chain
- Molecular classification
- Enzyme
01
Overview
The catalytic chain (PyrB) of Aspartate carbamoyltransferase (ATCase) catalyzes the first committed step in pyrimidine biosynthesis: the condensation of L-aspartate and carbamoyl phosphate to form N-carbamoyl-L-aspartate and inorganic phosphate. It is regulated allosterically by ATP and CTP. The holoenzyme consists of six catalytic chains organized as two trimers, along with six regulatory chains organized as three dimers.
- Other names
- PyrBAspartate transcarbamylase catalytic subunit
02
Mechanism of action
Inhibition of pyrimidine biosynthesis
03
Biological functions
CatalysisPyrimidine biosynthesis
04
Disease associations
Cancer
05
Interacting drugs
Phosphonoacetyl-L-aspartate (PALA)
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