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Aspartate decarboxylase (None)
- Target
- None
- Molecular classification
- Enzyme, Decarboxylase, Pyruvoyl-dependent decarboxylase
01
Overview
Aspartate decarboxylase (PanD) is an essential bacterial enzyme involved in vitamin B5 biosynthesis via conversion of L-aspartic acid into β-alanine, making it both vital for cellular metabolism and an attractive drug target, most notably implicated in mechanisms underlying antibiotic resistance.
- Other names
- Aspartate 1-decarboxylaseADCPanD
02
Mechanism of action
Inhibition of aspartate decarboxylase activity, leading to disruption of pantothenate synthesis and CoA production
03
Biological functions
Pantothenate/vitamin B5 biosynthesisCoenzyme A (CoA) productionCatalysis of L-aspartate to β-alanine
04
Disease associations
TuberculosisHelicobacter pylori infectionAntimicrobial resistance
05
Safety considerations
Development of resistance mutations (e.g., in Mycobacterium tuberculosis)
06
Interacting drugs
Pyrazinamide
2 more in the full profile.
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