Target intelligence / Profile preview

Aspartic peptidase retroviral like 1 (ASPRV1)

Target: ASPRV1
Molecular classification: Enzyme, Aspartic-type endopeptidase, Protease

Overview

ASPRV1 (Aspartic peptidase retroviral like 1) is a protein-coding gene that encodes a retroviral-like protease involved in the processing of profilaggrin to filaggrin, which is essential for skin barrier formation and maintenance. Its expression is localized mainly in the epidermis and hair follicles, and loss-of-function variants are implicated in congenital ichthyosis and other skin barrier disorders. It functions as an aspartic-type endopeptidase and is not known to be directly targeted by approved pharmaceuticals.

Other names: FLJ25084SASPASETAPS

Biological functions

Filaggrin processingSkin development and barrier maintenanceProtein processing

Disease associations

Autosomal Dominant IchthyosisAutosomal Recessive Congenital IchthyosisOther skin barrier defects

Beyond the preview

Go deeper on Aspartic peptidase retroviral like 1 (ASPRV1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Aspartic peptidase retroviral like 1 (ASPRV1).

Explore the full profile