Target intelligence / Profile preview

Aspartyl aminopeptidase

Molecular classification: Enzyme, Aminopeptidase

Overview

Aspartyl aminopeptidase (DNPEP) is a zinc-dependent exopeptidase that catalyzes the removal of N-terminal aspartic acid residues from peptides and proteins. It exhibits a strong preference for aspartate over glutamate at the P1 position. It plays a role in intracellular protein and peptide metabolism and participates in the renin-angiotensin system. Recent research suggests potential roles in cancer biology, including suppression of proliferation, invasion, and stemness of breast cancer cells.

Other names: ASPEPDAP

Biological functions

Intracellular protein/peptide metabolismRenin-angiotensin system (RAS) regulationHydrolysis of N-terminal aspartate residues

Disease associations

Cancer

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