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Assembly of bacterial ribosome

Molecular classification: Macromolecular complex, Ribosome biogenesis pathway

Overview

The assembly of the bacterial ribosome is a highly coordinated process essential for protein synthesis. It involves the synthesis, processing, and folding of rRNAs, the translation, folding, and binding of ribosomal proteins, and the action of assembly factors. Inhibition of this process is a target for novel antimicrobial agents.

Mechanism of action

Inhibition of ribosome assembly, leading to disruption of protein synthesis

Biological functions

Protein biosynthesismRNA translation

Disease associations

Infection

Safety considerations

Potential for off-target effects on eukaryotic ribosomesDevelopment of antibiotic resistance

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