Astrocyte ()

Astrocyte Overview

Astrocytes are a major subtype of glial cells in the central nervous system (CNS), recognized for their star-shaped morphology and extensive functional diversity. They play essential roles in maintaining CNS homeostasis, supporting neuronal function, and responding to injury. Astrocyte dysfunction contributes to various neuropathologies. Reactive astrogliosis, characterized by changes in gene expression profile (including upregulation of GFAP), hypertrophy/proliferation of astrocytic processes leading to glial scar formation can impede axonal regeneration but also limits spread of damage/inflammation.

Mechanism of Action

Biological Functions

Safety Considerations

Associated Biomarkers