AT-rich interaction domain-containing protein 1B (ARID1B)

AT-rich interaction domain-containing protein 1B (ARID1B) is a DNA-binding subunit and structural core of the SWI/SNF (also called BAF) ATP-dependent chromatin remodeling complex[1][2][4][5]. This complex regulates gene expression by altering chromatin structure, enabling or restricting DNA accessibility for transcription, DNA repair, and other nuclear processes[1][2]. ARID1B is critical for normal neural development, including neural stem cell proliferation, differentiation, and neural migration[1]. Germline mutations or haploinsufficiency of ARID1B cause Coffin–Siris syndrome, a multisystem neurodevelopmental disorder characterized by intellectual disability and distinctive physical features[4][5]. ARID1B functions as a tumor suppressor, and loss of ARID1B or SWI/SNF complex integrity is implicated in various human cancers[2][5]. The protein contains an ARID DNA-binding domain and participates in switching chromatin states, often mutually exclusively with its paralog ARID1A[1][5]. No direct ARID1B-targeted therapies are currently approved, and its essential role in cell identity and proliferation means any attempted therapeutic modulation would require caution[2][5].

Other names

AT-rich interaction domain 1BAT-rich interactive domain-containing protein 1BBAF250BDAN15KIAA1235OSA2hOsa2ELD/OSA1p250R6A3-5SMARCF2BRG1-associated factor 250bBRG1-binding protein hELD/OSA1Osa homolog 2BRIGHTCSS1MRD12

Not applicable (no known small-molecule drugs currently target ARID1B or its immediate chromatin-remodeling function in clinical use[5])