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AT-rich interaction domain-containing protein 4A (ARID4A)
- Target
- ARID4A
- Molecular classification
- DNA-binding protein, Transcriptional coregulator, Epigenetic regulator, Tumor suppressor
01
Overview
AT-rich interaction domain-containing protein 4A (ARID4A) is a ubiquitously expressed nuclear DNA-binding protein that modulates the activity of several transcription factors, notably the retinoblastoma protein (RB1) and androgen receptor. ARID4A acts as a transcriptional coregulator, playing a key role in transcriptional repression by recruiting histone deacetylases (HDACs) and mediating chromatin remodeling. It is involved in epigenetic regulation, spermatogenesis, hematopoiesis, and acts as a tumor suppressor in several contexts. Its dysfunction has been associated with various cancers, such as retinoblastoma and leukemia[1][3][4][5][6][7].
- Other names
- AT-rich interactive domain-containing protein 4ARBBP1RBP1Retinoblastoma-binding protein 1ARID domain-containing protein 4ARBBP-1RBP-1AT-rich interactive domain 4A (RBP1-like)
02
Mechanism of action
Transcriptional repression via HDAC recruitment; Epigenetic regulation through interaction with retinoblastoma protein (pRB) and chromatin modification complexes
03
Biological functions
Transcriptional repressionChromatin remodelingRegulation of cell proliferationSpermatogenesisRegulation of hematopoiesisEpigenetic modification
04
Disease associations
Cancer (notably retinoblastoma, leukemia, prostate cancer)Plasma cell neoplasmOther tumor suppressor-related pathologies
05
Safety considerations
Potential tumor suppressor loss-associated risks (e.g., increased cancer susceptibility)Uncertainty regarding off-target or systemic effects when modulating ARID4A function
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