AT-rich interaction domain-containing protein 5A (ARID5A)

AT-rich interaction domain-containing protein 5A (ARID5A) is a dual-function nucleic acid binding protein belonging to the ARID protein family, characterized by its DNA- and RNA-binding AT-rich interaction domain[2][5]. In the nucleus, ARID5A acts as a transcription factor or corepressor by binding to AT-rich promoter sequences, regulating gene expression and chromatin state[2][6]. Upon inflammatory stimulation, ARID5A translocates to the cytoplasm, where it stabilizes specific pro-inflammatory mRNA transcripts—especially those of IL6, STAT3, and TBX21—by binding to their 3′ untranslated regions and blocking mRNA decay[1][3][5][6]. Through these post-transcriptional and transcriptional actions, ARID5A plays critical roles in immune regulation, inflammatory diseases, chondrocyte differentiation (often cooperating with SOX9), and suppression of estrogen receptor (ER)-mediated signaling[1][3][5][6]. Its pathological involvement has been linked to conditions such as autoimmune disorders, septic shock, various cancers (including breast cancer via effects on invasion and metastasis), and metabolic diseases like obesity. ARID5A is considered a potential therapeutic target, particularly in settings of inflammatory and autoimmune pathologies, though clinical targeting remains under investigation[1][5].

Other names

AT-rich interaction domain 5AModulator recognition factor 1MRF1ARID domain-containing protein 5AMRF-1RP11-363D14modulator recognition factor 1modulator recognition factor IMRF1-likeRFVG5814

Stabilization of pro-inflammatory mRNAs such as IL6, STAT3, TBX21; Transcriptional regulation by binding to promoter regions; Modulation of estrogen receptor and other nuclear hormone receptors