AT-rich interaction domain-containing protein 5B (ARID5B)

AT-rich interaction domain-containing protein 5B (ARID5B) is a member of the ARID family of DNA-binding proteins involved in transcriptional regulation and chromatin remodeling[3][4]. ARID5B acts as a transcriptional coactivator that can form a complex with PHF2 to demethylate histone H3K9me2, leading to activation of target gene expression, influencing processes such as adipogenesis, liver development, chondrogenesis, energy metabolism, and hematopoiesis[2][3][4]. ARID5B plays a critical role in B-cell development, differentiation, and survival, with mouse models showing that both overexpression and loss of function disrupt lymphocyte development and metabolism[1]. Genetic variation in ARID5B is one of the strongest and most consistent germline risk factors for childhood acute lymphoblastic leukemia, especially B-cell lineage ALL, and is implicated in additional disease susceptibilities including obesity, autoimmune disease, and cardiovascular diseases[1][3][4]. As a nuclear factor, it participates in broad regulatory networks but is not presently considered a direct therapeutic target by existing small molecules or targeted drugs[3].

Other names

AT-rich interaction domain 5BDESRTMRF2MRF-2FLJ21150MRF1-like proteinmodulator recognition factor 2ARID domain-containing protein 5BAT-rich interactive domain-containing protein 5BMRF1-like