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Target intelligence / Profile preview
Ataxia Telangiectasia Mutated kinase (ATM)
- Target
- ATM
- Molecular classification
- Serine/threonine protein kinase, PIKK family member
01
Overview
ATM is a large serine/threonine protein kinase that plays a central role in the cellular response to DNA double-strand breaks (DSBs) and other forms of cellular stress. It acts as a key initiator and coordinator of DNA damage signaling, cell cycle checkpoints, DNA repair, and apoptosis. Mutations in the ATM gene cause ataxia-telangiectasia (A-T), a rare neurodegenerative disorder characterized by cerebellar degeneration/ataxia, immune deficiency, radiosensitivity, and high cancer predisposition. ATM also regulates immune functions, such as repressing IL‑23 secretion in dendritic cells.
02
Biological functions
DNA damage responseCell cycle checkpoint controlDNA repairApoptosisImmune modulationGenome stability
03
Disease associations
Ataxia-telangiectasiaCancerImmunodeficiencyNeurodegeneration
04
Safety considerations
Inhibition may disrupt DNA damage responsePotential for off-target effects
05
Biomarkers
ATM expression levelsATM phosphorylation status (e.g., Ser1981)
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