Ataxin-10 (ATXN10)

Ataxin-10 is a cytoplasmic protein encoded by the ATXN10 gene, best known for its association with spinocerebellar ataxia type 10 (SCA10), a neurodegenerative disorder caused by expansion of a pentanucleotide (ATTCT) repeat in its intronic region[1][3][5]. Ataxin-10 plays roles in neuron survival, neuronal differentiation, and neuritogenesis, partially through activation of the mitogen-activated protein kinase (MAPK) cascade and interaction with G protein subunits[1][3][4]. It is also essential for proper cytokinesis and coordinates cell cycle events, interacting with mitotic regulators such as polo-like kinase 1 (Plk1) and Aurora B kinase[1]. In SCA10, toxic intronic RNA expansions sequester RNA-binding proteins, leading to RNA processing defects and apoptosis. Ataxin-10 is broadly expressed, with particular importance during embryonic development and in the nervous system. There are no known direct interacting drugs as of the latest reports, and it is not currently a validated therapeutic target.

Other names

Ataxin-10SCA10E46LFLJ37990ATX10Brain protein E46 homologSpinocerebellar ataxia type 10 proteinHUMEEPataxin-10brain protein E46 homologspinocerebellar ataxia type 10 protein