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Ataxin-3 mRNA (ATXN3 mRNA)

Target: ATXN3 mRNA
Molecular classification: mRNA, Transcript

Overview

Ataxin-3 mRNA encodes the ataxin-3 protein, a deubiquitinating enzyme (DUB) involved in various cellular processes. The gene is known as ATXN3 and is most notably associated with the neurodegenerative disorder Machado–Joseph disease (MJD), also called spinocerebellar ataxia type 3 (SCA3). The pathogenic role arises primarily when mutations/expansions occur within this mRNA’s coding sequence leading to altered protein products that aggregate abnormally.

Other names: ATXN3 transcriptMachado-Joseph disease protein 3 mRNASCA3 mRNA

Mechanism of action

N/A

Biological functions

Encoding of deubiquitinating enzymeRegulation of protein homeostasis (indirect)Regulation of transcription (indirect)Maintenance of genomic stability (indirect)

Disease associations

Machado-Joseph disease/SCA3 (indirect)Neurodegenerative disease (indirect)Testicular cancer (indirect)Breast cancer (indirect)Gastric cancer (indirect)Thyroid cancer (indirect)

Safety considerations

N/A - mRNA itself does not pose direct safety concerns, but its encoded protein does when mutated.

Biomarkers

ATXN3 mRNA levels (potential)CAG repeat length in ATXN3 mRNA

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