Ataxin 8 opposite strand long non-coding RNA (ATXN8OS)

Ataxin 8 opposite strand long non-coding RNA (ATXN8OS) is an antisense transcript located on chromosome 13q21. It is classified as a long non-coding RNA (lncRNA) and does not encode a protein. ATXN8OS has pleiotropic roles in normal physiology and disease. In spinocerebellar ataxia type 8 (SCA8), expanded trinucleotide repeats in ATXN8OS are pathogenic, leading to neurodegeneration[2]. In cancer, ATXN8OS is overexpressed and acts via competing endogenous RNA (ceRNA) mechanisms, notably by sequestering microRNAs such as miR-204, which results in enhanced cell proliferation and invasion in breast cancer[1]. In gliomas, ATXN8OS suppresses temozolomide resistance by promoting ferroptosis through the ADAR/GLS2 pathway[3]. Functionally, ATXN8OS is implicated in cell cycle regulation and can serve as a prognostic biomarker in cancer. There are currently no drugs directly targeting ATXN8OS, but its molecular interactions offer promising therapeutic and diagnostic opportunities.

Other names

Putative protein ATXN8OSKLHL1ASSCA8NCRNA00003ATXN8 opposite strand (non-protein coding)Spinocerebellar ataxia 8kelch-like 1 antisensenon-protein coding RNA 3ataxin 8 opposite strand

Acts as a ceRNA by sequestering specific microRNAs (notably miR-204) to regulate downstream targets; Regulates chemoresistance and ferroptosis in glioma through ADAR/GLS2 pathway