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Target intelligence / Profile preview
ATF7 antisense RNA 1 (ATF7-AS1)
- Target
- ATF7-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
ATF7 antisense RNA 1 (ATF7-AS1) is a long non-coding RNA transcribed in the antisense direction relative to the ATF7 gene locus. Unlike the ATF7 protein, ATF7-AS1 does not encode a protein but is involved in the regulation of gene expression—often through mechanisms like RNA interference, chromatin remodeling, or acting as a molecular sponge for microRNAs. Functional studies suggest that ATF7-AS1 may play a role in the progression of several cancers, with its upregulation being associated with increased tumor growth and poor prognosis in certain malignancies. Its potential to influence gene regulation places it as a candidate biomarker in oncology, but there are no current therapies targeting ATF7-AS1 directly.
- Other names
- ATF7-AS1LncRNA ATF7-AS1
02
Mechanism of action
Not applicable (no drugs target this non-coding RNA directly)
03
Biological functions
Negative regulation of gene expression via antisense mechanismsModulation of ATF7 gene expressionPossible roles in cancer cell proliferation and migration (as suggested by functional studies in some tumor types)Regulation of transcription (epigenetic and post-transcriptional levels)
04
Disease associations
Cancer (ATF7-AS1 has been implicated in tumor progression in several cancers, including gastric, colorectal, breast, and non-small cell lung cancers)Other (potential role in gene regulation and disease development through epigenetic modulation)
05
Biomarkers
ATF7-AS1 expression may serve as a biomarker for cancer prognosis or disease progression in certain cancer types (such as colorectal or gastric cancer)
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