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Target intelligence / Profile preview
Atos homolog protein B (ATOSB)
- Target
- ATOSB
- Molecular classification
- Other (protein-coding gene; predicted transcription regulator; non-enzymatic and non-receptor)
01
Overview
Atos homolog protein B (ATOSB, also known as FAM214B) is a nuclear protein encoded by the FAM214B gene on human chromosome 9p13.3. It has a predicted function as a transcription regulator, containing a DUF4210 domain with a possible role in chromosome segregation during meiosis, although its precise biological function remains unclear. The protein is primarily localized in the nucleus and is highly expressed in the brain, bone marrow, placenta, and several other tissues, both during development and in adults. Several transcript and protein isoforms exist, with some evidence indicating altered expression patterns in neuropsychiatric and renal diseases. Although ATOSB interacts with some environmental chemicals and several cellular proteins, there is no evidence it serves as a drug target or is involved in classic receptor, enzyme, ion channel, or transporter pathways.
- Other names
- FAM214BKIAA1539FLJ11560bA182N22.6BA182N22.6PI.11659_5LOC80256RP11-182N22.6atos homolog protein Bfamily with sequence similarity 214 member Bprotein FAM214B
02
Biological functions
Transcription regulation (transcription regulator that may synchronize transcriptional and translational programs)Chromosome segregation in meiosis (predicted function of the DUF4210 domain, not experimentally confirmed)Potential role in cell development and differentiation (based on tissue expression in brain, bone marrow, and developmental stages)
03
Disease associations
Major depressive disorder (altered expression correlated with vulnerability to depression)Bipolar disorder (significantly higher expression in some brain regions)Diabetic nephropathy (elevated expression in affected patients)Allergic response (lower expression in patients with nasal allergy to dust mites)Other (not definitively associated with cancer or other common therapeutic areas; limited published disease roles)
04
Interacting drugs
Bisphenol A
2 more in the full profile.
05
Biomarkers
Potential biomarker for major depressive disorder (expression levels linked to disease states)Potential biomarker for bipolar disorder and diabetic nephropathy in preliminary studies
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