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Target intelligence / Profile preview
ATP-binding cassette sub-family A member 8 (ABCA8)
- Target
- ABCA8
- Molecular classification
- Transporter, ATP-binding cassette transporter, Membrane protein
01
Overview
ATP-binding cassette sub-family A member 8 (ABCA8) is a membrane-associated transporter belonging to the ABC transporter family, specifically the ABC1 subfamily, and is primarily involved in transporting organic anions, regulating lipid metabolism, and promoting cholesterol and sphingomyelin homeostasis[1][2][3][4][5]. ABCA8 is widely expressed, with particularly high levels in brain white matter, liver, heart, and skeletal muscle. In the central nervous system, it promotes sphingomyelin synthesis in oligodendrocytes, contributing to myelination. ABCA8 also mediates ATP-dependent transport of substances such as taurocholate, estrone sulfate, and ochratoxin A, with its roles spanning xenobiotic clearance and lipid trafficking. Disease associations include several cancers (often as a tumor suppressor gene), myelination disorders, and certain lipid metabolism disorders. While not currently a drug target, its activity influences chemoresistance and tumor progression in some contexts[3].
- Other names
- ABC-type organic anion transporter ABCA8KIAA0822ATP-binding cassette, sub-family A (ABC1), member 8ATP-binding cassette subfamily A member 8
02
Mechanism of action
ATP-dependent transport of organic anions (e.g., taurocholate, estrone sulfate, ochratoxin A); Regulates efflux/import of cholesterol and other lipids
03
Biological functions
Lipid transportOrganic anion transportCholesterol effluxSphingomyelin productionRegulation of lipid metabolism
04
Disease associations
CancerNeurodegenerative diseaseCardiovascular diseaseCongenital ichthyosis
05
Safety considerations
No specific drug-targeting safety concerns are reported in the current literature. Possible theoretical issues relate to the wide role in lipid homeostasis and brain myelination, indicating a need for caution if ever targeted therapeutically, as perturbation could affect neural lipid metabolism and myelin maintenance[1][4][5].
06
Interacting drugs
No clinically approved drugs are documented to target ABCA8 directly. It can transport drug-like compounds and related substrates, such as certain bile salts and xenobiotics, in cellular studies[2][3][4].
07
Biomarkers
ABCA8 expression is implicated as part of a gene expression panel for distinguishing breast fibroepithelial lesions[1].Expression/protein levels may serve as biomarkers in neurodegenerative disease (multiple system atrophy) and several cancers[3].
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