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Target intelligence / Profile preview
ATP-binding cassette sub-family B member 1 (ABCB1)
- Target
- ABCB1
- Molecular classification
- ATP-Binding Cassette Transporter, Transporter
01
Overview
ABCB1, also known as P-glycoprotein or MDR1, is a membrane-bound transporter protein belonging to the ATP-binding cassette (ABC) superfamily. It functions as an ATP-dependent efflux pump, transporting a wide variety of substrates—including drugs and toxins—out of cells. This activity plays a crucial role in cellular detoxification and protection against toxic substances. ABCB1 is clinically significant due to its role in multidrug resistance in cancer and its impact on drug pharmacokinetics.
- Other names
- P-glycoproteinP-gpMultidrug resistance protein 1MDR1
02
Mechanism of action
ATP-dependent efflux pump for xenobiotic compounds; inhibitors compete for the binding pocket or interfere with ATPase activity.
03
Biological functions
Xenobiotic transportDrug effluxCellular detoxificationProtection against toxic substances
04
Disease associations
CancerMultidrug resistance
05
Safety considerations
Drug-drug interactions due to altered pharmacokineticsDevelopment of multidrug resistance in cancerAltered drug absorption and distribution
06
Interacting drugs
Chemotherapeutics
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