Target intelligence / Profile preview

ATP-binding cassette sub-family C member 10 (ABCC10)

Target: ABCC10
Molecular classification: ABC Transporter, Transporter, ATP-binding cassette transporter superfamily, Membrane protein

Overview

ABCC10/MRP7 is a clinically relevant transmembrane protein whose main function is active export of diverse compounds—including many anticancer drugs—out of cells using energy from ATP hydrolysis. This activity underlies its prominent role both physiologically and pathologically—in particular contributing significantly to multidrug resistance phenotypes seen during cancer therapy. Additionally it may play roles outside oncology related to lipid metabolism regulation.

Other names: MRP7Multidrug Resistance Protein 7

Mechanism of action

ATP-dependent efflux pump; actively transports substrates out of cells, reducing intracellular accumulation of drugs.

Biological functions

Drug effluxMultidrug resistanceLipid metabolism regulationXenobiotic transport

Disease associations

CancerAtherosclerosisMultidrug resistanceMetabolic disease

Safety considerations

Overexpression can lead to multidrug resistance in cancer therapy.Inhibition may affect other physiological processes due to its broad substrate profile.Potential impact on lipid metabolism

Interacting drugs

Docetaxel

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Biomarkers

ABCC10 expression level in tumor cellsABCC10 expression in atherosclerotic lesions

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