ATP-binding cassette sub-family C member 10 (ABCC10) (ABCC10)

ATP-binding cassette sub-family C member 10 (ABCC10), also known as Multidrug resistance-associated protein 7 (MRP7), is a transmembrane protein that functions as an ATP-dependent efflux pump [1, 5]. It belongs to the C subfamily of the ABC transporter superfamily and is characterized by its ability to transport a broad spectrum of substrates, including amphipathic anions and various xenobiotics [1, 2]. In the context of oncology, ABCC10 is a significant mediator of multidrug resistance (MDR), as it actively extrudes several classes of chemotherapeutic agents such as taxanes (paclitaxel and docetaxel), vinca alkaloids, and epipodophyllotoxins from cancer cells [2, 3]. This efflux activity lowers the intracellular concentration of these drugs, thereby diminishing their cytotoxic effects and leading to treatment failure [3, 4]. Beyond its role in cancer, ABCC10 is expressed in normal tissues like the liver, lung, and gastrointestinal tract, where it likely contributes to the protection of cells from toxic substances [1, 5]. Research into ABCC10 inhibitors aims to reverse drug resistance and enhance the efficacy of existing chemotherapies, although maintaining selectivity to avoid systemic toxicity remains a primary challenge [4]. Sources: [1] UniProt (Q5T3U5); [2] Hopper-Borge et al. (2004) Cancer Res; [3] Kruh et al. (2007) Cancer Metastasis Rev; [4] Kathawala et al. (2015) Mol Cancer Ther; [5] NCBI Gene (ID: 124411).

Other names

Multidrug resistance-associated protein 7MRP7ABC20SIMRP7

ABCC10 functions as an ATP-dependent efflux pump that transports chemotherapeutic agents out of the cell, thereby reducing their intracellular accumulation and conferring resistance to treatment [1, 3].