ATP-binding cassette sub-family C member 11 (ABCC11)

ATP-binding cassette sub-family C member 11 (ABCC11) is an ATP-dependent membrane transporter belonging to the multidrug resistance-associated protein (MRP) subfamily of the large ATP-binding cassette (ABC) transporter superfamily. ABCC11 actively effluxes a broad range of lipophilic anions—including cyclic nucleotides, steroid sulfates, bile acid conjugates, and xenobiotics—across cellular membranes. It plays key physiological roles in bile acid and steroid transport, and is uniquely associated with human phenotypes such as earwax type (wet or dry) and axillary odor due to its involvement in secretion from apocrine glands. In tissues such as the brain, ABCC11 facilitates neurosteroid release. Clinically, it can mediate chemoresistance by extruding nucleoside-based antineoplastic agents (such as 5-fluorouracil and methotrexate), making it a relevant pharmacological target for modulating drug disposition and efficacy. A common polymorphism (538G>A) in the gene impacts both visible traits (earwax, body odor) and potentially clinical drug responses.

Other names

Multidrug resistance-associated protein 8MRP8EWWDWWMulti-resistance protein 8ATP-binding cassette protein C11ATP-binding cassette transporter MRP8ATP-binding cassette transporter sub-family C member 11

Efflux of nucleoside-based anticancer drugs and metabolites, mediating drug resistance. ATP-dependent translocation of physiological and xenobiotic organic anions across cell membranes. Extrusion of drug conjugates that can confer multidrug resistance in tumor cells.