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Target intelligence / Profile preview
ATP-binding cassette sub-family C member 2 (ABCC2)
- Target
- ABCC2
- Molecular classification
- ATP-binding cassette (ABC) transporter, MRP subfamily, Transporter
01
Overview
ATP-binding cassette sub-family C member 2 (ABCC2), also known as multidrug resistance-associated protein 2 (MRP2) or canalicular multispecific organic anion transporter (cMOAT), is a membrane-bound transporter protein that plays a critical role in the efflux of various endogenous and exogenous compounds from cells. It is predominantly expressed on the apical membrane of hepatocytes, renal proximal tubular cells, enterocytes and syncytiotrophoblasts. Its primary function is to mediate the export of conjugated organic anions, contributing significantly to detoxification. Mutations in ABCC2 are associated with Dubin-Johnson syndrome. Overexpression can contribute to multidrug resistance during chemotherapy.
- Other names
- Multidrug resistance-associated protein 2MRP2Canalicular multispecific organic anion transportercMOATcMRPDJS
02
Mechanism of action
Inhibition of organic anion transport; Transport of drugs and metabolites across cell membranes
03
Biological functions
Drug metabolism and clearanceBilirubin transportEfflux of conjugated organic anionsDetoxificationChemoprotection
04
Disease associations
Dubin-Johnson syndromeMultidrug resistance in cancer
05
Safety considerations
Drug-drug interactions due to altered drug dispositionMultidrug resistance in cancer chemotherapyAltered bilirubin homeostasis
06
Interacting drugs
Probenecid
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