ATP-binding cassette sub-family C member 5 (ABCC5) (ABCC5)

ATP-binding cassette sub-family C member 5 (ABCC5), also known as Multidrug resistance-associated protein 5 (MRP5), is a transmembrane protein that functions as an ATP-dependent efflux transporter (UniProt: P51467). It is widely expressed in various tissues, including the brain, heart, and kidneys, where it plays a crucial role in the transport of cyclic nucleotides like cGMP and cAMP, thereby regulating intracellular signaling pathways (PubMed: 10751356). In the context of oncology, ABCC5 is significant for its ability to export several chemotherapeutic agents, particularly nucleoside analogs such as 5-fluorouracil and 6-mercaptopurine, contributing to multidrug resistance (MDR) (PubMed: 12538899). Beyond cancer, ABCC5 has been implicated in cardiovascular health and metabolic processes due to its regulation of cyclic nucleotide levels (PubMed: 15145511). Pharmacological modulation of ABCC5, such as inhibition by phosphodiesterase-5 inhibitors like sildenafil, represents a strategy to overcome drug resistance or modulate signaling (PubMed: 14744681). However, targeting ABCC5 requires careful consideration of potential systemic effects on normal physiological processes governed by cyclic nucleotides, such as vascular tone and neurotransmission.

Other names

Multidrug resistance-associated protein 5MRP5Multi-specific organic anion transporter CMOAT-CSMRPpABC11

ATP-dependent efflux of substrates across the plasma membrane against a concentration gradient