ATP-binding cassette sub-family C member 6 (ABCC6)

ATP-binding cassette sub-family C member 6 (ABCC6) is a transmembrane protein predominantly expressed in the liver and kidney, where it acts as an ATP-dependent efflux transporter for organic anions and possibly other yet unidentified substrates[2][4][7][9]. ABCC6 is a member of the ABC transporter superfamily, specifically the MRP (multidrug resistance-associated protein) subfamily that actively transports molecules across cell membranes using ATP hydrolysis[1][3][4]. Its physiological function includes regulation of extracellular nucleotide levels—particularly via ATP release and subsequent pyrophosphate production—playing a critical role in mineralization homeostasis. Pathogenic variants of ABCC6 cause pseudoxanthoma elasticum (PXE), a heritable disorder characterized by abnormal calcification of connective tissues, and are also associated with early-onset atherosclerosis[2][4][5]. ABCC6 has no well-established direct pharmacological inhibitors or activators in current medical use, but its role in drug resistance and substrate efflux may have clinical implications.

Other names

ABCC6Multidrug resistance-associated protein 6 (MRP6)Multi-specific organic anion transporter-E (MOAT-E)Anthracycline resistance-associated protein (ARA)ABC34EST349056MLP1PXEPXE1URG7

Drugs/compounds that modulate ABCC6 function would likely affect cellular efflux of anionic substrates or modulate systemic levels of pyrophosphate and nucleotides, influencing mineralization and drug resistance phenotypes[1][4][7].