Target intelligence / Profile preview

ATP-binding cassette sub-family C member 9

Molecular classification: ATP-binding cassette transporter superfamily, MRP subfamily, Ion channel regulatory subunit

Overview

ABCC9 encodes the sulfonylurea receptor 2 (SUR2), a regulatory subunit of ATP-sensitive potassium (KATP) channels. These channels regulate potassium ion transport across cell membranes in response to intracellular ATP levels, crucial for cellular excitability and metabolic sensing. Mutations in ABCC9 are associated with various diseases, including Cantú syndrome, familial dilated cardiomyopathy, and intellectual disability/myopathy syndrome (AIMS).

Other names: ABCC9Sulfonylurea receptor 2 (SUR2)ABC37ATFB12CANTUCMD1OSUR2IDMYS

Mechanism of action

Regulates the opening and closing of KATP channels based on intracellular ATP levels, thereby affecting potassium ion flux and cellular excitability.

Biological functions

Potassium ion transport regulationMetabolic sensingRegulation of KATP channel activityModulation of calcium ion concentration

Disease associations

Cantú syndromeFamilial dilated cardiomyopathyFamilial atrial fibrillationBrugada syndromeIntellectual disability/myopathy syndrome (AIMS)

Safety considerations

Gain-of-function mutations can lead to abnormal channel opening and altered tissue excitability.Loss-of-function mutations can impair neurodevelopment and muscle function.

Interacting drugs

Sulfonylureas (indirectly via KATP channels)

Beyond the preview

Go deeper on ATP-binding cassette sub-family C member 9.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on ATP-binding cassette sub-family C member 9.

Explore the full profile