ATP-binding cassette sub-family F member 1 (ABCF1)

ATP-binding cassette sub-family F member 1 (ABCF1) is a non-transmembrane member of the ATP-binding cassette (ABC) protein superfamily, specifically classified within the GCN20 subfamily. Unlike most ABC transporters, ABCF1 lacks transmembrane domains and is not involved in classic membrane transport. Instead, it facilitates mRNA translation initiation through ATP-dependent interaction with eukaryotic initiation factor 2 (eIF2), functions as a cell-specific transcriptional coactivator in pluripotent stem cells, and acts as an E2 ubiquitin-conjugating enzyme modulating immune responses and inflammation, particularly via regulation of Toll-like receptor 4 (TLR4) signaling in macrophages. ABCF1 expression is regulated by inflammatory cytokines such as TNF-alpha, and is essential for development and immune function; loss-of-function causes embryonic lethality in mice. Pathophysiologically, it can influence cytokine production during infection or sepsis and may indirectly affect conditions involving immune dysregulation and inflammation. No approved drugs are known to directly target ABCF1.

Other names

ABC50ATP-binding cassette 50TNF-alpha-stimulated ABC proteinABC27EST123147ATP-binding cassette, sub-family F (GCN20), member 1TNFalpha-inducible ATP-binding protein

Not established for drugs, but molecular mechanisms include ATP binding/hydrolysis for conformational change; E2 ubiquitin conjugating activity (regulates TLR4 signaling in sepsis)