Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
ATP-binding cassette sub-family F member 3 (ABCF3)
- Target
- ABCF3
- Molecular classification
- ATPase, ABC (ATP-binding cassette) transporter superfamily—subfamily F, Regulatory protein (not a transporter, channel, or receptor)
01
Overview
ATP-binding cassette sub-family F member 3 (ABCF3) is a cytoplasmic protein in the ABC transporter superfamily, subfamily F, that functions primarily as an active ATPase, with dual nucleotide-binding domains. Unlike most ABC proteins, ABCF3 lacks transmembrane domains and does not function as a transporter. ABCF3 is involved in cell proliferation and regulates lipid-sensitive ATP hydrolysis, possibly contributing to antiviral resistance, proliferation, and other intracellular processes, particularly by interacting with other proteins such as OAS1B and members of the tumor protein D52 family[2][3][5].
- Other names
- ATP-binding cassette sub-family F member 3ABCF3EST201864GCN20
02
Mechanism of action
Not applicable; no established drugs target ABCF3 directly. ABCF3's activity is regulated by lipids (sphingosine, sphingomyelin, platelet-activating factor), but not by amphiphilic drugs[2].
03
Biological functions
Cell proliferation (ABCF3 enhances cell growth, partly by interacting with proteins such as the tumor protein D52 family)Modulation of antiviral response (ABCF3 can interact with proteins involved in resistance to flaviviruses in mouse models)Regulation of ATP hydrolysis in response to lipid signalsProtein–protein interactions
04
Disease associations
Cancer (ABCF3 positively regulates cell proliferation, suggesting a potential role in tumorigenesis)Infection (ABCF3 is implicated in cellular resistance to viruses such as flaviviruses in animal studies)Other (generic regulatory mechanisms in cellular growth)
Beyond the preview
Go deeper on ATP-binding cassette sub-family F member 3 (ABCF3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ATP-binding cassette sub-family F member 3 (ABCF3).