ATP-binding cassette sub-family G member 1 (ABCG1)

ATP-binding cassette sub-family G member 1 (ABCG1) is a membrane-associated, half-transporter protein primarily responsible for exporting cholesterol and phospholipids from cells to extracellular acceptors like high-density lipoproteins (HDL) through ATP hydrolysis[1][3][5]. Essential for macrophage cholesterol efflux, ABCG1 is also involved in regulating cellular lipid levels and preventing cytotoxic lipid accumulation[1][5]. It acts predominantly as a homodimer and can form heterodimers with related transporters, such as ABCG4[3]. Beyond lipid metabolism, elevated ABCG1 expression is linked to tumor progression, chemoresistance, stem-like properties in cancer cells, and immune modulation, making it a noteworthy therapeutic target and disease biomarker[7].

Other names

ATP-binding cassette transporter 8ABC8White protein homologATP binding cassette subfamily G member 1 (Gene name: ABCG1)

Promotes efflux of cholesterol and phospholipids to extracellular acceptors (e.g., HDL) via ATP hydrolysis[3][5]. Modulates cholesterol homeostasis, and in cancer, mediates chemoresistance and stemness acquisition[7].