ATP-binding cassette subfamily A member 7 (ABCA7)

ATP-binding cassette subfamily A member 7 (ABCA7) is a large membrane-spanning transporter protein that belongs to the ABC1 subfamily of ATP-binding cassette transporters[1][2][3][4]. ABCA7 functions primarily in lipid homeostasis and is especially important in the immune system, facilitating translocation of phospholipids and possibly cholesterol across cell membranes, as well as promoting phagocytosis of apoptotic cells and amyloid-beta clearance, particularly in microglia and macrophages[1][3]. Genetic variants in ABCA7 are strongly associated with increased risk for late-onset Alzheimer’s disease, likely through altered lipid regulation and impaired clearance of amyloid-beta peptides[2][3]. ABCA7 is mainly expressed in myeloid and lymphoid tissues, including leukocytes, thymus, spleen, and bone marrow[1][3]. Although indirect modulation by statins is documented, there are currently no clinically established drugs that directly target ABCA7. Disruption of ABCA7 function is associated with neurodegeneration and immune defects, cautioning against untargeted modulation in therapeutic development[3].

Other names

ABCA7ABCA-SSNABCX

Modulation of phospholipid and cholesterol efflux (via ATP hydrolysis) Indirect immunomodulation (by altering phagocytosis and immune cell function) Influence on amyloid-beta clearance and processing