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Target intelligence / Profile preview
ATP-binding cassette transporter C8 (ABCC8)
- Target
- ABCC8
- Molecular classification
- ABC transporter, MRP subfamily, Regulatory subunit, Ion channel regulator
01
Overview
ABCC8 encodes the sulfonylurea receptor 1 (SUR1), a regulatory subunit of the ATP-sensitive potassium channel (KATP channel) in pancreatic beta cells. The KATP channel is crucial for coupling cell metabolism to electrical activity and insulin secretion. Mutations in ABCC8 can cause congenital hyperinsulinism, neonatal diabetes, and other disorders of glucose homeostasis.
- Other names
- Sulfonylurea receptor 1SUR1HRINSSURSUR1delta2ABC36TNDM2MRP8HHF1PHHI
02
Mechanism of action
Sulfonylureas bind to SUR1, closing the KATP channel and stimulating insulin release.
03
Biological functions
Regulation of KATP channel activityRegulation of insulin secretionGlucose homeostasis
04
Disease associations
Congenital hyperinsulinismNeonatal diabetes mellitusHyperinsulinemic hypoglycemia of infancyType II diabetes mellitus
05
Safety considerations
HypoglycemiaDrug-induced hyperinsulinism
06
Interacting drugs
Sulfonylureas
2 more in the full profile.
07
Biomarkers
ABCC8 mutations for diagnosis of congenital hyperinsulinism and neonatal diabetesExpression levels in pancreatic beta cells
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