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Target intelligence / Profile preview
ATP-binding cassette transporter sub-family C member 8 (ABCC8/SUR1)
- Target
- ABCC8/SUR1
- Molecular classification
- ATP-binding cassette transporter, Transporter, Regulatory subunit, Ion channel subunit
01
Overview
ABCC8 (SUR1) is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, primarily found in pancreatic beta cells. It plays a crucial role in glucose-stimulated insulin secretion by controlling membrane potential in response to intracellular ATP/ADP levels. Mutations in ABCC8 are associated with congenital hyperinsulinism and permanent neonatal diabetes mellitus. It is also a target for sulfonylurea drugs used in the treatment of type 2 diabetes.
- Other names
- SUR1MRP8HIPHHITNDM2Sulfonylurea receptor 1
02
Mechanism of action
Sulfonylureas bind to SUR1, causing closure of KATP channels, which leads to membrane depolarization and increased insulin secretion.
03
Biological functions
Regulation of KATP channel activityModulation of insulin secretionRegulation of membrane potentialGlucose homeostasis
04
Disease associations
Congenital hyperinsulinismPermanent neonatal diabetes mellitus
05
Safety considerations
Hypoglycemia (due to excessive insulin release)Potential for drug interactions
06
Interacting drugs
Sulfonylureas
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