Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
ATP-binding cassette transporter sub-family C member 9 (ABCC9/SUR2)
- Target
- ABCC9/SUR2
- Molecular classification
- ABC transporter superfamily, MRP subfamily, Regulatory subunit, Ion channel subunit
01
Overview
ATP-binding cassette transporter sub-family C member 9 (ABCC9/SUR2), also known as sulfonylurea receptor 2 (SUR2), is a regulatory subunit of ATP-sensitive potassium (K-ATP) channels. These channels link cellular metabolism to membrane excitability, and ABCC9/SUR2 plays a crucial role in regulating their activity. It is expressed in various tissues, including cardiac muscle, skeletal muscle, and smooth muscle, and mutations in ABCC9 are associated with Cantú syndrome, familial atrial fibrillation, and intellectual disability/myopathy syndrome. It is a target of drugs such as sulfonylureas and vasodilators.
- Other names
- Sulfonylurea receptor 2ABC37ATFB12CANTUCMD1OSUR2ASUR2B
02
Mechanism of action
Modulation of K-ATP channel opening via direct interaction with the SUR subunit
03
Biological functions
Regulation of ATP-sensitive potassium channelsRegulation of membrane potentialRegulation of calcium ion concentrationsLinking cellular metabolism to membrane excitability
04
Disease associations
Cantú syndromeFamilial atrial fibrillationIntellectual disability/myopathy syndrome
05
Safety considerations
Extrapancreatic effects of sulfonylureasAltered channel gating in Cantú syndromeImpaired K‑ATP channel function in intellectual disability/myopathy syndrome
06
Interacting drugs
Sulfonylureas
1 more in the full profile.
Beyond the preview
Go deeper on ATP-binding cassette transporter sub-family C member 9 (ABCC9/SUR2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on ATP-binding cassette transporter sub-family C member 9 (ABCC9/SUR2).