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Target intelligence / Profile preview
ATP-dependent DNA helicase DDX11 (DDX11)
- Target
- DDX11
- Molecular classification
- Enzyme, DNA helicase, ATPase, DEAD/H-box helicase family
01
Overview
ATP-dependent DNA helicase DDX11 is a member of the DEAD/H-box helicase family that unwinds DNA for replication and repair, thus maintaining genomic stability. DDX11 also promotes proper sister chromatid cohesion and chromosome segregation, and plays key roles in DNA double-strand break repair, rRNA transcription, and heterochromatin organization. Loss of DDX11 function causes Warsaw breakage syndrome, a rare developmental disorder involving genome instability, growth failure, and multiple congenital abnormalities; it may also play a role in some cancers due to its role in DNA replication and genome integrity.
- Other names
- CHL1ChlR1CHLR1KRG2KRG-2hCHLR1WABSDEAD/H-box protein 11DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11DNA 5'-3' helicase DDX11keratinocyte growth factor-regulated gene 2 proteinCHL1-like helicase homolog (S. cerevisiae)CHL1-related protein 1CHL1-related helicase gene-1probable ATP-dependent DNA helicase DDX11probable ATP-dependent RNA helicase DDX11Warsaw breakage syndrome
02
Mechanism of action
Not applicable; no drugs are known to selectively target DDX11.
03
Biological functions
DNA replicationDNA repairSister chromatid cohesionChromosome segregationGenome stability maintenanceHeterochromatin organizationrRNA transcription activationCell division
04
Disease associations
Warsaw breakage syndromeCancer (genome instability roles, involvement in melanoma cell proliferation and survival)Other rare developmental disorders (e.g., periventricular heterotopia with microcephaly)
05
Safety considerations
Loss-of-function mutations can cause Warsaw breakage syndrome (growth impairment, microcephaly, developmental anomalies, hearing loss, heart defects, chromosome instability)Essential role in genome maintenance, so inhibition could result in severe chromosome instability and cytotoxicity in normal cells
06
Biomarkers
Mutations in DDX11 are biomarkers for Warsaw breakage syndromeDDX11 function or expression may also be studied as a marker of genome stability in cancer but no established clinical biomarkers for patient selection.
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