ATP-dependent DNA helicase Q5 (RECQL5)

ATP-dependent DNA helicase Q5 (RECQL5) is an enzyme belonging to the RecQ family of helicases, which play major roles in the maintenance of genomic integrity. RECQL5 is involved in regulating DNA repair, homologous recombination, replication, transcription, and chromosomal segregation[1][2][3][6]. It is unique among RecQ helicases in its interactions with RNA polymerase II and its ability to inhibit both transcription initiation and elongation, thereby reducing transcriptional stress and protecting genome stability in actively transcribed regions[1][2][5]. RECQL5 can unwind various DNA structures, promotes strand exchange and annealing activities, and suppresses inappropriate homologous recombination, especially at stalled or damaged replication forks[3][4][6]. Its function as a tumor suppressor is increasingly appreciated, and defects in RECQL5 lead to chromosomal instability and increased susceptibility to cancer. The gene has several isoforms, with RECQ5β being the predominant form localized to the nucleus[6]. No specific pharmacological agents targeting RECQL5 are clinically available; however, RECQL5's roles in DNA metabolism make it a promising research target for cancer therapeutics and genome integrity modulation.

Other names

RECQL5RECQ5RecQ5FLJ90603DNA 3'-5' helicase RecQ5DNA helicase, RecQ-like type 5RecQ protein-like 5RecQ protein 5RecQ helicase-like 5

Not applicable; no drugs targeting RECQL5 currently established