ATP-dependent energy metabolism

ATP-dependent energy metabolism is the fundamental biological process by which cells generate adenosine triphosphate (ATP) through pathways such as glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation [PMID: 29123077]. It is not a single molecular target but rather a complex network of enzymes and transporters that maintain cellular energy homeostasis. In diseases like cancer, cells often undergo metabolic reprogramming, such as the Warburg effect, to support rapid proliferation [PMID: 20305636]. Therapeutic strategies often target specific nodes within this metabolism, such as ATP synthase or AMP-activated protein kinase (AMPK), to treat metabolic disorders or selectively kill malignant cells [PMID: 30585048]. However, because these pathways are essential for the survival of all healthy cells, targeting them presents significant challenges regarding systemic toxicity and the therapeutic window [PMID: 27112567].

Other names

Cellular respirationBioenergeticsOxidative phosphorylationGlycolysis

Modulation of ATP production through the inhibition or activation of specific enzymes and transporters within the glycolytic and mitochondrial respiratory chains [PMID: 30585048].