ATP-dependent RNA helicase DDX19B (DDX19B)

ATP-dependent RNA helicase DDX19B is a member of the DEAD-box protein family characterized by the conserved motif "Asp-Glu-Ala-Asp" (DEAD). It functions as an RNA helicase with ATPase activity and is involved in numerous RNA metabolic processes, particularly the export of mRNA from the nucleus to the cytoplasm. Rather than unwinding RNA duplexes in a classical sense, DDX19B remodels ribonucleoprotein particles by displacing proteins from nuclear mRNA and facilitating the loading of cytoplasmic mRNA-binding proteins. This process is essential for the regulated trafficking and maturation of mRNAs. DDX19B is recruited to the cytoplasmic fibrils of the nuclear pore complex and plays a crucial role in translation initiation, pre-mRNA splicing, ribosome assembly, and possibly other aspects of RNA metabolism. Dysfunction or altered expression of DDX19B may contribute to disease, most notably certain cancers, though the evidence for this is currently limited

Other names

DEAD-box helicase 19BDBP5DDX19RNAhTDBPDEAD5DEAD box protein 19BDEAD-box RNA helicase DEAD5DEAD box protein 5 homolog (S. cerevisiae)ATP-dependent RNA helicase DDX19DEAD (Asp-Glu-Ala-As) box polypeptide 19BDEAD (Asp-Glu-Ala-Asp) box polypeptide 19BDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (Dbp5, yeast, homolog)yeast Dbp5 homolog

ATP-dependent RNA unwinding Remodeling of ribonucleoprotein particles (RNPs), facilitating the replacement of nuclear mRNA-binding proteins with cytoplasmic ones during export