ATP-dependent RNA helicase DHX33 (DHX33)

ATP-dependent RNA helicase DHX33 is a member of the DEAH box family of RNA helicases characterized by the Asp-Glu-Ala-His (DEAH) motif[2][4]. DHX33 functions as an essential enzyme in multiple aspects of RNA metabolism, including unwinding secondary structures in RNA to promote translation initiation, facilitating ribosome biogenesis via nucleolar organization, and sensing cytosolic double-stranded RNA to activate immune responses such as NLRP3 inflammasome formation and type I interferon production[1][2][3][4]. DHX33 is required for global protein synthesis, cell growth, and proliferation, and is induced by oncogenic signaling pathways. It is involved in both normal cellular physiology and disease, notably as a critical driver in cancer and inflammation, and represents a promising therapeutic target due to its central role in mRNA translation and cell proliferation[1][3][4][5].

Other names

DEAH-box helicase 33DDX33FLJ21972DKFZp762F2011DEAH box protein 33DEAD/H box polypeptide 33DEAH box protein 33, putative

Inhibition of DHX33 helicase activity impairs ribosome biogenesis and disrupts mRNA translation, leading to reduced protein synthesis and cell proliferation[1][4][5]. Activation of ferroptosis pathway (for KY386)[5].