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Target intelligence / Profile preview
ATP-sensitive inward rectifier potassium channel (KATP channel)
- Target
- KATP channel
- Molecular classification
- Potassium channel, Ion channel, Inward rectifier potassium channel
01
Overview
The ATP-sensitive inward rectifier potassium channel (KATP channel) is a potassium ion channel that links cellular metabolism to electrical activity. It is composed of Kir6.x and SUR subunits, gated by intracellular ATP/ADP levels, and plays a crucial role in regulating membrane potential and various physiological processes in tissues like the heart, pancreas, brain, and smooth muscle. Mutations and dysfunctions are associated with diseases such as neonatal diabetes and cardiac arrhythmias.
- Other names
- KATPATP-sensitive K+ channelInwardly rectifying potassium channel, ATP-sensitive
02
Mechanism of action
Regulation of potassium ion flow across the cell membrane based on intracellular ATP/ADP levels. Blocked by sulfonylureas, activated by certain vasodilators.
03
Biological functions
Membrane potential regulationCoupling cellular metabolic state to electrical excitabilityPotassium ion transportRegulation of insulin secretionRegulation of vascular tonePotassium buffering
04
Disease associations
Neonatal diabetesCongenital hyperinsulinismArrhythmiasDilated cardiomyopathy after ischemia/reperfusion injuryCoronary artery vasospasmSudden deathIschemia/reperfusion injury
05
Safety considerations
ArrhythmiasPotential for hypoglycemia with sulfonylureasCardiac dysfunction
06
Interacting drugs
Diazoxide
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