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Target intelligence / Profile preview
Potassium Inwardly Rectifying Channel Subfamily J Member 1 (KCNJ1)
- Target
- KCNJ1
- Molecular classification
- Ion channel, Potassium channel, Inwardly Rectifying Potassium Channel
01
Overview
KCNJ1 encodes an inwardly rectifying potassium channel, primarily expressed in the kidney, that plays a crucial role in potassium homeostasis and fluid balance. Mutations in KCNJ1 are associated with Bartter syndrome type II and may influence hypertension risk. The channel is regulated by intracellular ATP and phosphorylation.
- Other names
- ROMKROMK1ATP-sensitive inward rectifier potassium channel 1
02
Mechanism of action
Modulated by ATP and phosphorylation/dephosphorylation events.
03
Biological functions
Ion transportPotassium homeostasisRegulation of membrane potentialRenal ion transportFluid balance regulationLymph pump activity
04
Disease associations
Bartter Syndrome Type IIHypertensionDiabetes (possible link)Electrolyte imbalance
05
Safety considerations
Electrolyte imbalancesSalt wastingPotential for off-target effects in other tissues expressing KCNJ1
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