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Target intelligence / Profile preview
ATP-sensitive Inward Rectifier Potassium Channel 8 (Kir6.1)
- Target
- Kir6.1
- Molecular classification
- Ion channel, Potassium channel, Inward rectifier potassium channel
01
Overview
ATP-sensitive inward rectifier potassium channel 8 (Kir6.1) is a subunit of the ATP-sensitive potassium (K_ATP) channel. K_ATP channels link cellular metabolism to electrical activity by responding to intracellular ATP and ADP levels. These channels are hetero-octameric complexes composed of four Kir6.x subunits (like Kir6.1) and four regulatory SUR subunits. They are crucial in various tissues like heart, vasculature, skeletal muscle, and brain, regulating potassium ion flow, stabilizing resting membrane potential, and protecting against metabolic stress.
- Other names
- KCNJ8uKATP-1
02
Mechanism of action
Activators (openers) or blockers (inhibitors) of the K_ATP channel affecting potassium ion flow across the cell membrane, thus altering cellular excitability.
03
Biological functions
Regulation of ion transmembrane transportVasodilationResponse to pH changesSynaptic transmission modulationRegulation of vascular tonePotassium ion homeostasisRegulation of cellular excitability
04
Disease associations
Cardiovascular diseaseDiabetes mellitusMigraine
05
Interacting drugs
Levosimendan
8 more in the full profile.
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