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Target intelligence / Profile preview
ATP-sensitive potassium channel regulatory subunit SUR1 (SUR1)
- Target
- SUR1
- Molecular classification
- ABC transporter, Regulatory subunit, Ion channel regulator
01
Overview
The ATP-sensitive potassium channel regulatory subunit SUR1 is a regulatory component of the K_ATP channel, an octameric complex of four Kir6.2 and four SUR1 subunits. It regulates the K_ATP channel's activity by linking cellular metabolism to membrane excitability. SUR1 is the molecular target of sulfonylurea drugs used in type 2 diabetes. Mutations in ABCC8/SUR1 can cause congenital hyperinsulinism or neonatal diabetes. Additionally, SUR1 plays a role in cardiac tissue under stress.
- Other names
- Sulfonylurea receptor 1ABCC8
02
Mechanism of action
Sulfonylureas and glinides bind to SUR1, causing closure of K_ATP channels in pancreatic beta cells, leading to depolarization and insulin release.
03
Biological functions
Regulation of K_ATP channel activityLinking cellular metabolism to membrane excitabilityRegulation of insulin secretion
04
Disease associations
Congenital hyperinsulinismNeonatal diabetesMyocardial infarctionType 2 diabetes
05
Interacting drugs
Sulfonylureas
1 more in the full profile.
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