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Target intelligence / Profile preview
ATP-sensitive Potassium Channel Subunit SUR1 (SUR1)
- Target
- SUR1
- Molecular classification
- ABC transporter superfamily, Ion channel subunit, Regulatory protein
01
Overview
The ATP-sensitive potassium (K(ATP)) channel subunit SUR1 is a regulatory protein that forms part of the K(ATP) channel complex. This complex is crucial for linking cellular metabolism to electrical activity in various cell types, most notably pancreatic β-cells, neurons, and some cardiac tissues. The K(ATP) channel itself is an octameric structure composed of four pore-forming Kir6.x subunits (typically Kir6.2 in β-cells) and four regulatory sulfonylurea receptor (SUR) subunits—SUR1 being the predominant isoform in pancreatic β-cells.
- Other names
- Sulfonylurea receptor 1ABCC8
02
Mechanism of action
Sulfonylureas inhibit channels containing SUR1; Diazoxide activates channels containing SUR1.
03
Biological functions
Regulation of KATP channel activitySensing intracellular nucleotidesCoupling metabolic state with membrane excitabilityRegulation of insulin secretion
04
Disease associations
Congenital hyperinsulinismNeonatal diabetes mellitusMyocardial infarction-induced damage
05
Interacting drugs
Tolbutamide
4 more in the full profile.
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