ATP synthase F1 complex subunit gamma, mitochondrial (ATP5F1C)

ATP synthase F1 complex subunit gamma (ATP5F1C) is a nuclear-encoded mitochondrial protein forming the central rotor shaft of the ATP synthase holoenzyme. This subunit physically connects the F0 rotary motor embedded in the mitochondrial inner membrane to the F1 catalytic core, transmitting rotary motion driven by proton translocation to facilitate conformational changes in catalytic sites and enable ATP production. It is essential for cellular bioenergetics, with mutations linked to mitochondrial diseases and metabolic disorders. As an integral part of the catalytic machinery, it is a potential therapeutic target, although strategies must account for its fundamental role in cellular viability[1][2][3][4].

Other names

ATP synthase F(1) complex subunit gamma, mitochondrialATP synthase F1 subunit gammaATP5CATP5C1ATP synthase gamma chain, mitochondrialATP synthase subunit gamma, mitochondrialF-ATPase gamma subunitATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1Mitochondrial ATP synthase gamma subunit 1ATP5CL1

Inhibition of ATP synthase activity: Blocking rotary action or proton translocation halts ATP production. Allosteric inhibition: Drugs binding the F0 motor prevent rotation of the gamma subunit, stopping catalysis.