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Target intelligence / Profile preview
ATP synthase mitochondrial F1 complex assembly factor 1 (ATPAF1)
- Target
- ATPAF1
- Molecular classification
- Other (assembly factor, mitochondrial protein, not itself an enzyme, receptor, or transporter)
01
Overview
ATP synthase mitochondrial F1 complex assembly factor 1 (ATPAF1) is a nuclear-encoded mitochondrial protein required for the assembly of the F1 catalytic portion of mitochondrial ATP synthase. ATPAF1 specifically interacts with the F1 beta subunit, preventing its nonproductive aggregation and enabling correct assembly of the ATP synthase complex. This factor is essential for proper mitochondrial ATP production but is not itself an enzyme, receptor, or transporter. Several alternatively spliced transcript variants exist; however, the biological significance of some is unclear. No evidence identifies ATPAF1 as a direct drug target, disease biomarker, or therapeutic agent[1].
- Other names
- ATP11 homologATP11FLJ22351Atp11pATP11pATPAF1ATP synthase mitochondrial F1 complex assembly factor 1homolog of yeast ATP11
02
Biological functions
Mitochondrial ATP synthase complex assemblyPrevention of nonproductive homooligomerization of F1 beta subunitMitochondrial energy metabolism
03
Disease associations
Other (no established direct disease association as a therapeutic target; defects in ATP synthase assembly have been linked to mitochondrial diseases, but direct disease associations with ATPAF1 are not prominent in the literature[1])
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