ATP synthase peripheral stalk subunit F6 (F6)

ATP synthase peripheral stalk subunit F6 is a nuclear-encoded protein component of the mammalian mitochondrial ATP synthase complex (complex V). It forms a critical part of the peripheral stalk (stator), which anchors the enzyme’s catalytic head (F1 sector) to the membrane sector (FO) and prevents its rotation as protons drive rotary catalysis for synthesis of ATP from ADP and inorganic phosphate[1][2]. F6 interacts with other stator proteins such as subunit b, OSCP, and subunit d. Mutation or loss of F6 disrupts complex assembly and coupling between proton movement and ATP production, severely impairing mitochondrial function[2]. Although ATP synthase is a validated therapeutic target in some contexts (especially in infectious disease and cancer research), direct small-molecule targeting of the F6 subunit has not been reported, and inhibitors act broader on the complex. F6 is encoded in humans by the ATP5J gene and is analogous to subunit h in yeast[2].

Other names

Subunit F6ATP synthase subunit F6ATP5J (gene symbol)Peripheral stalk subunit F6Subunit h (yeast ortholog)

Inhibition of ATP synthase (prevents ATP production by disrupting proton channel or complex stability)