ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP5PO)

ATP synthase peripheral stalk subunit OSCP, mitochondrial (ATP5PO), is a crucial structural and regulatory protein subunit of the mitochondrial ATP synthase complex (F1FO, Complex V). OSCP acts as a stator within the peripheral stalk, mechanically linking the catalytic F1 core to the membrane-embedded FO channel and maintaining complex integrity and coupling during rotary catalysis. The protein regulates sensitivity of the enzyme to oligomycin and modulates the opening of the mitochondrial permeability transition pore, interacting with agents such as cyclophilin D and Bz-423. Downregulation or dysfunction of OSCP is associated with mitochondrial disease, neurodegeneration (notably Alzheimer's disease), and cellular energy failure. The protein is encoded by the ATP5PO gene located on the long arm of chromosome 21.

Other names

ATP synthase peripheral stalk subunit OSCPATP5POATP5OATPOOSCPATP synthase subunit OOligomycin sensitivity conferral proteinOligomycin sensitivity conferring protein

Inhibition of ATP synthase (by drugs such as oligomycin, effects conferred structurally by OSCP, but without direct ligand binding). Modulation of mitochondrial permeability transition pore (PTP) opening via interactions with cyclophilin D and Bz-423 at OSCP. Regulated by post-translational modifications such as acetylation and protonation of specific residues.