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ATPase Copper Transporting Alpha (ATP7A)
- Target
- ATP7A
- Molecular classification
- Enzyme, Transporter, P-type ATPase
01
Overview
ATP7A is a copper-transporting P-type ATPase that regulates copper levels in the body by transporting copper ions across cellular membranes. It is essential for supplying copper to cuproenzymes involved in various physiological processes, and its dysfunction leads to diseases like Menkes disease.
- Other names
- Copper-transporting ATPase 1Copper pump 1Menkes disease-associated proteinMNK
02
Mechanism of action
Omeprazole blocks the activity of ATP7A, potentially altering copper homeostasis.
03
Biological functions
Copper transportRegulation of copper homeostasisCofactor delivery to cuproenzymes
04
Disease associations
Menkes diseaseOccipital horn syndromeX-linked distal spinal muscular atrophyNeurodegenerative diseaseConnective tissue disorders
05
Safety considerations
Copper imbalanceNeurological complicationsConnective tissue abnormalities
06
Interacting drugs
Omeprazole
07
Biomarkers
Copper levelsATP7A expressionActivity of cuproenzymes
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