ATPase family AAA domain-containing protein 1 (ATAD1)

ATPase family AAA domain-containing protein 1 (ATAD1; also known as Thorase and Msp1) is a highly conserved AAA+ ATPase predominantly localized to the outer membrane of mitochondria and peroxisomes[1][3][4]. It plays a crucial role in cellular homeostasis and mitochondrial function by recognizing and extracting mislocalized tail-anchored membrane proteins, facilitating their degradation or correct retargeting and thereby preserving mitochondrial integrity[1][2][3][4]. In neurons, ATAD1 also regulates synaptic plasticity by disassembling postsynaptic protein complexes and controlling the internalization of AMPA receptors, which is critical for processes such as learning and memory[1][2][4]. ATAD1 is considered a potential therapeutic target in diseases associated with mitochondrial dysfunction and neurological disorders, as well as in cancer, reflecting its multifaceted roles in protein quality control and cellular signaling[1][4].

Other names

ThoraseMsp1Outer mitochondrial transmembrane helix translocaseFNP001hATAD1FLJ14600AFDC1HKPX4ATPase family AAA domain containing 1