ATPase family AAA domain-containing protein 2 (ATAD2)

ATPase family AAA domain-containing protein 2 (ATAD2) is a multidomain nuclear protein with a canonical AAA+ ATPase domain and a unique bromodomain (BRD) that reads acetylated lysines on histones[1][2][3][4]. It functions primarily as a chromatin remodeler and transcriptional coactivator for nuclear hormone receptors (estrogen, androgen receptors) and key oncogenic transcription factors (c-Myc, E2F), facilitating gene expression programs that promote cell proliferation and survival[1][4][5][8]. ATAD2 is upregulated in many cancers and correlates with poor prognosis, making it an emerging anticancer drug target—especially through its bromodomain, which is critical for recognizing acetylated histone tails[1][2][3][4]. ATAD2 participates in DNA replication, histone chaperoning, and chromatin remodeling, making it central to epigenetic regulation and tumorigenesis[1][2][3][4][5][7][8]. Drug discovery efforts focus on developing bromodomain inhibitors to block its oncogenic functions.

Other names

ANCCAL16PRO2000DKFZp667N1320MGC5254MGC29843CT137AAA nuclear coregulator cancer-associated protein

Inhibition of bromodomain binding to acetylated histones Suppression of chromatin remodeling and transcriptional activation in cancer cells